Biochem/physiol Actions

Primary Target→₂-adrenoceptor

General description

A non-selective antagonist for α₂-adrenoceptors (pKi = 8.01, 7.43, and 7.7 for α_2A, α_2B, and α_2C receptors respectively) and imidazoline receptors. (pKi = 5.90, 7.22 for I₁ and I₂, receptors respectively). Widely used in studying functions of the nervous systems, such as learning and memory, decision making, reward, attention, addiction, depression, and schizophrenia related to the adrenergic receptors, and blood pressure regulation, pain modulation, and neuroprotection related to the imidazoline receptors.

A non-selective antagonist for ?₂-adrenoceptors (pKi = 8.01, 7.43, and 7.7 for ?_2A, ?_2B, and ?_2C receptors respectively) and imidazoline receptors. (pKi = 5.90, 7.22 for I₁ and I₂, receptors respectively). Widely used in studying functions of the nervous systems, such as learning and memory, decision making, reward, attention, addiction, depression, and schizophrenia related to the adrenergic receptors, and blood pressure regulation, pain modulation, and neuroprotection related to the imidazoline receptors.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Humpston, S., et al. 2013. J. of Psychopharmacology, 27, 213.Dabir, l., 1986. J.Pharmacol.17, 113.Michel, M., et al. 1992. TIPS13, 369.Eglen, R., et al. 1998. TiPS19, 381.Doxey, J., et al. 1984. Br J Pharmacol. 1984. 83, 713.Gadie, B., 1984. Br J Pharmacol.83, 707.

Packaging

50 mg in Glass bottle

Reconstitution

Following reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Toxic (F)